An Alternative, Non-Apoptotic Form of Programmed Cell Death
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چکیده
Traditional thought about cell death focuses on two distinct types of events. Apoptosis is characterized by distinct morphological characteristics and specific genetic events; necrosis is described by different morphological characteristics and a lack of genetic control of the death process. However some forms of cell death, including oncosis and some developmental and neurodegenerative cell deaths, do not fit morphological descriptions of necrosis or apoptosis. The biochemical mechanisms by which these alternative cell deaths occur are unknown. In this study, the authors describe a form of cell death that requires gene expression but does not conform to morphological and biochemical criteria for apoptosis.
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